CJC 1295 with DAC 5mg

€32.99

Technical Specifications

Specification	Detail
Product Name	CJC-1295 with DAC
Quantity	5mg per vial
Purity	≥98% (HPLC verified)
Form	Lyophilized powder, no additives
Molecular Weight	~3647 Da
CAS Number	446262-90-4
Amino Acid Sequence	YADAXFXQSYRKVLAQLSARKLLQDXLSR (simplified)
Solubility	Sterile water; DMSO: 10 mM
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	-80°C for long-term; avoid repeated freeze-thaw
Shelf Life	3 years from manufacture date
Half-Life (Research)	~6-8 days
Shipping	Ice packs with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

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Description

Description

Premium CJC-1295 DAC Peptide for Sale | 5mg Lyophilized Powder | ≥98% Purity | 48-Hour Delivery Across EU & UK

CJC-1295 with DAC: The Long-Acting GHRH Analog for Advanced Endocrine Research

eupeptidelap.co.uk is proud to present CJC-1295 with DAC 5mg, a premium research-grade growth hormone-releasing hormone (GHRH) analog manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with CJC-1295 DAC for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in endocrinology, metabolism, and cellular growth .

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids with a molecular weight of approximately 3647 Da . What distinguishes this peptide from other GHRH analogs is the presence of the Drug Affinity Complex (DAC) moiety—a lysine derivative that enables the peptide to bind covalently to serum albumin, the most abundant protein in plasma . This binding dramatically extends the peptide’s half-life from minutes to approximately 6-8 days in humans, providing sustained stimulation of the anterior pituitary gland .

The peptide incorporates strategic amino acid substitutions that enhance its stability and biological activity: D-alanine at position 2 prevents DPP-IV enzyme cleavage, glutamine at position 8 reduces asparagine rearrangement, alanine at position 15 increases biological action, and leucine at position 27 prevents methionine oxidation . These modifications, combined with the DAC technology, create a remarkably stable peptide that resists rapid degradation and maintains prolonged bioavailability .

CJC-1295 with DAC works by binding to GHRH receptors on somatotroph cells in the anterior pituitary gland, stimulating the secretion of growth hormone (GH) in a sustained manner . The elevated GH levels subsequently increase production of insulin-like growth factor 1 (IGF-1), the primary mediator of GH’s anabolic effects . Clinical studies have demonstrated that a single injection of CJC-1295 can increase plasma GH levels by 2- to 10-fold for 6 days or longer, and plasma IGF-1 levels by 0.5- to 3-fold for 9 to 11 days .

For researchers seeking to buy peptide online EU for investigations into growth hormone dynamics, metabolic regulation, cellular aging, or tissue regeneration, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of CJC-1295 with DAC Research

Molecular Architecture and Design

CJC-1295 with DAC represents a sophisticated advancement in GHRH analog design. The peptide is based on the biologically active 1-29 fragment of endogenous GHRH but incorporates key modifications that fundamentally alter its pharmacokinetic profile .

Drug Affinity Complex (DAC) Technology: The defining feature of this peptide is the DAC moiety—a lysine derivative linked to a reactive chemical called maleimidoproprionic acid (MPA) that enables covalent binding to circulating albumin after subcutaneous injection . This albumin-binding property protects the peptide from rapid enzymatic degradation and renal clearance, allowing it to circulate in the bloodstream for extended periods .

Structural Modifications: Beyond the DAC technology, CJC-1295 incorporates four strategic amino acid substitutions that enhance its stability and biological activity :

D-alanine at position 2: Prevents cleavage by dipeptidyl peptidase IV (DPP-IV), the primary enzyme responsible for degrading endogenous GHRH
Glutamine at position 8: Reduces asparagine rearrangement and amide hydrolysis
Alanine at position 15: Increases biological potency and receptor binding affinity
Leucine at position 27: Prevents methionine oxidation, preserving structural integrity

These combined modifications create a peptide with dramatically improved pharmacokinetics—extending the half-life from approximately 30 minutes for unmodified GHRH to an estimated 6-8 days for CJC-1295 with DAC .

Mechanism of Action

CJC-1295 with DAC functions as a potent GHRH receptor agonist, binding to receptors on somatotroph cells in the anterior pituitary gland . This binding initiates intracellular signaling cascades that stimulate the synthesis and release of growth hormone.

The prolonged presence of the peptide in the bloodstream, facilitated by albumin binding, provides sustained stimulation of the pituitary gland, leading to elevated GH levels over extended periods . The increased GH secretion subsequently stimulates hepatic and peripheral production of insulin-like growth factor 1 (IGF-1), which mediates many of GH’s anabolic effects .

Pharmacokinetic Profile

The pharmacokinetic properties of CJC-1295 with DAC are remarkable compared to other GHRH analogs:

Parameter	CJC-1295 with DAC	Unmodified GHRH / No DAC Versions
Half-Life	~6-8 days in humans	~30 minutes
GH Elevation	2- to 10-fold for 6+ days	Brief, pulsatile
IGF-1 Elevation	0.5- to 3-fold for 9-11 days	Transient
Dosing Frequency	Once weekly or less	Multiple times daily
Mechanism	Albumin binding via DAC	No albumin binding

Physiological Effects

Through sustained GH and IGF-1 elevation, CJC-1295 with DAC influences multiple physiological processes relevant to research :

Protein Synthesis: Stimulates the production of new proteins, supporting cellular growth and tissue maintenance
Muscle Growth: Promotes lean muscle mass accretion through anabolic pathways
Fat Metabolism: Enhances lipolysis and fat breakdown, influencing body composition
Bone Density: Supports increased bone mineral content and collagen production
Immune Function: May modulate immune system activity through GH effects

Key Research Applications

Endocrine and Growth Hormone Dynamics Research

CJC-1295 with DAC serves as a sophisticated tool for investigating growth hormone physiology and regulation. Its extended half-life allows researchers to study sustained GH elevation and its downstream effects without the confounding variables of frequent dosing . Applications include:

Characterizing GH-IGF-1 axis feedback mechanisms under prolonged stimulation
Investigating pulsatile versus sustained GH release patterns
Studying GH receptor signaling pathways and desensitization

Metabolic Research and Body Composition Studies

Growth hormone plays a fundamental role in regulating metabolism, and CJC-1295 with DAC offers a unique platform for exploring these mechanisms . Research applications include:

Lipolysis and Fat Metabolism: GH stimulates the breakdown of triglycerides into free fatty acids, making this peptide valuable for studying fat metabolism and energy homeostasis . The sustained GH elevation may provide insights into long-term adipose tissue regulation.

Insulin Sensitivity and Glucose Uptake: CJC-1295 with DAC has been hypothesized to influence insulin sensitivity and glucose metabolism in certain laboratory settings, offering a tool for investigating the complex relationship between GH and glucose homeostasis .

Muscle Protein Synthesis: The peptide’s anabolic effects on muscle tissue make it relevant for research into muscle growth, maintenance, and recovery mechanisms .

Cellular Aging and Longevity Research

The age-related decline in growth hormone secretion, known as somatopause, is a universal hallmark of biological aging linked to reduced cellular repair, loss of bone density, and decreased cognitive vitality . CJC-1295 with DAC has emerged as a primary molecule of interest in cellular aging research.

By potentially restoring GH and IGF-1 levels to a more youthful profile, the peptide provides a framework for investigating strategies to mitigate age-related decline . In experimental models, researchers have observed improvements in mitochondrial function and reductions in oxidative stress when using this research peptide, offering insights into how we might support the longevity of aging cells .

Neurodegenerative Disease Research

The nervous system is particularly sensitive to hormonal fluctuations. Both GH and IGF-1 are known to impact neuronal survival, myelination, and synaptic plasticity . CJC-1295 with DAC’s potential to support these levels has led to its inclusion in neurodegenerative research.

Preliminary data suggests that the peptide might impact pathways involved in neuronal repair, positioning it as a candidate for exploring interventions in conditions like Alzheimer’s and Parkinson’s disease . There is also strong focus on the peptide’s hypothesized anti-inflammatory properties, which may provide a basis for neuroprotective strategies .

Cardiovascular Research

GH influences vascular tone and the health of the endothelium, the thin layer of cells lining blood vessels—dysregulation here is a primary precursor to hypertension and atherosclerosis . CJC-1295 with DAC is theorized to support endothelial function by reducing cellular stress within vascular walls.

Researchers are investigating whether the sustained release of GH facilitated by the DAC modification can help maintain vascular elasticity and protect against the oxidative damage that leads to plaque buildup .

Tissue Regeneration and Wound Healing

Growth hormone plays an essential role in cellular growth and repair processes, making CJC-1295 with DAC valuable for studies focused on tissue regeneration and recovery from injury . The sustained presence of the peptide may support long-term cellular growth processes by providing continuous GH stimulation, which may be helpful for investigating regenerative mechanisms over extended periods in muscular tissue, bone, or connective tissue repair .

Sleep and Circadian Rhythm Research

CJC-1295 with DAC has been shown to stimulate slow wave sleep—the period of sleep when most of the body’s recovery takes place in muscles, tissues, and cartilage . This property makes it relevant for research into sleep architecture, recovery physiology, and the relationship between GH secretion and sleep patterns.

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources CJC-1295 with DAC 5mg from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥98% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation (~3647 Da) via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Sterile Manufacturing: Lyophilized with no additives; sterile filtered
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	CJC-1295 with DAC (Drug Affinity Complex)
CAS Number	446262-90-4
Molecular Formula	C₁₆₅H₂₆₉N₄₇O₄₆
Molecular Weight	~3647 Da
Amino Acid Length	30 amino acids
Purity	≥98% (HPLC verified)
Appearance	White lyophilized powder
Form	Lyophilized powder with no additives
Solubility	Soluble in sterile 18MΩ-cm H₂O; DMSO: 10 mM
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	-80°C for long-term; avoid repeated freeze-thaw
Half-Life	~6-8 days in humans (research context)
Shipping	Ice packs with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized CJC-1295 with DAC powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 3 years from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile 18MΩ-cm H₂O or appropriate buffer according to research protocol
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution and concentration
For storage, aliquot and store at -80°C

Reconstituted Solution Storage: Store reconstituted peptide solutions at -80°C for long-term stability . Avoid repeated freeze-thaw cycles by aliquoting into single-use portions. Solutions in DMSO (10 mM) should be handled according to standard laboratory protocols.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥98% HPLC-verified purity
Long-Acting GHRH Analog: DAC moiety enables albumin binding, extending half-life to ~6-8 days
Sustained GH Release: Single administration elevates GH for 6+ days and IGF-1 for 9-11 days
Enhanced Stability: Strategic amino acid substitutions prevent enzymatic degradation
Endocrine Research: Ideal for studying GH-IGF-1 axis dynamics and feedback mechanisms
Metabolic Studies: Investigate lipolysis, fat metabolism, and body composition
Muscle Growth Research: Stimulates protein synthesis and lean muscle accretion
Cellular Aging Research: Explore strategies to mitigate age-related decline and somatopause
Neurodegenerative Disease Research: Investigate neuroprotective pathways in Alzheimer’s and Parkinson’s models
Cardiovascular Research: Study endothelial function and vascular health
Tissue Regeneration: Supports research into muscle, bone, and connective tissue repair
Bone Density Studies: Promotes collagen production and bone mineral content
Sleep Research: Stimulates slow wave sleep and recovery processes
No Prolactin Elevation: Unlike some secretagogues, does not increase prolactin levels
Synergistic Potential: Can be combined with GHRPs for enhanced GH release studies
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is CJC-1295 with DAC and how does it differ from CJC-1295 without DAC?

A: CJC-1295 with DAC (Drug Affinity Complex) is a long-acting GHRH analog containing a lysine derivative that enables binding to serum albumin, extending its half-life to approximately 6-8 days . CJC-1295 without DAC (often referred to as Mod GRF 1-29) lacks this albumin-binding moiety and has a much shorter half-life of about 30 minutes, producing more natural pulsatile GH release .

Q: What is the mechanism of action of CJC-1295 with DAC?

A: CJC-1295 with DAC binds to GHRH receptors on somatotroph cells in the anterior pituitary gland, stimulating sustained growth hormone secretion . The DAC moiety binds covalently to serum albumin, protecting the peptide from rapid degradation and allowing prolonged circulation . The elevated GH then stimulates hepatic and peripheral production of IGF-1, which mediates many anabolic effects .

Q: What purity level can I expect when I buy CJC-1295 with DAC from eupeptidelap.co.uk?

A: All CJC-1295 with DAC 5mg from eupeptidelap.co.uk is tested to ≥98% purity by HPLC . Each batch is individually analyzed, and Certificates of Analysis are provided with every order, ensuring you receive material suitable for rigorous research applications.

Q: What is the half-life of CJC-1295 with DAC?

A: The estimated half-life of CJC-1295 with DAC is approximately 6-8 days in humans . A single injection has been shown to increase plasma GH levels for 6 days or longer and plasma IGF-1 levels for 9 to 11 days .

Q: How should I store CJC-1295 with DAC for long-term stability?

A: Store lyophilized CJC-1295 with DAC powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 3 years. After reconstitution, aliquot into single-use portions and store at -80°C . Avoid repeated freeze-thaw cycles.

Q: What is the recommended reconstitution protocol for CJC-1295 with DAC?

A: Reconstitute using sterile 18MΩ-cm H₂O or appropriate buffer. For DMSO-based formulations, note that DMSO solubility is 10 mM . Allow vials to reach room temperature, inject solvent slowly down the vial wall to minimize foaming, and gently swirl until dissolved. Do not shake vigorously.

Q: What research areas commonly use CJC-1295 with DAC?

A: CJC-1295 with DAC is widely used in endocrine research (GH-IGF-1 axis dynamics), metabolic studies (lipolysis, fat metabolism), muscle growth and protein synthesis research, cellular aging and longevity studies, neurodegenerative disease research, cardiovascular research, tissue regeneration studies, and sleep research .

Q: Is CJC-1295 with DAC legal to purchase in the UK?

A: CJC-1295 with DAC is sold strictly for research purposes only and is not approved for human consumption by the MHRA in the UK or the FDA in the US . At eupeptidelap.co.uk, all products are intended for research and laboratory use only.

Q: Do you ship CJC-1295 with DAC to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship CJC-1295 with DAC 5mg to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use ice packs with protective packaging to maintain compound integrity during transit .

Q: What documentation do you provide with CJC-1295 with DAC orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data. Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Does CJC-1295 with DAC affect prolactin levels?

A: Unlike some GHRP-class peptides, CJC-1295 with DAC has been shown to increase growth hormone and IGF-1 levels without increasing prolactin . This makes it particularly valuable for endocrine research where prolactin elevation would be a confounding variable.

Q: Can CJC-1295 with DAC be combined with other peptides in research?

A: Yes. Research indicates that combining CJC-1295 with DAC with GHRP peptides (such as GHRP-6 or Ipamorelin) can significantly increase GH and IGF-1 production without prolactin elevation . This synergistic approach is valuable for studying enhanced GH release mechanisms .

Q: Do you offer bulk quantities of CJC-1295 with DAC for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

Advance Your Research with CJC-1295 with DAC 5mg

eupeptidelap.co.uk is your trusted source for CJC-1295 with DAC 5mg, the premium choice for researchers investigating growth hormone dynamics, metabolic regulation, cellular aging, and tissue regeneration. With its unique DAC moiety enabling sustained GH release and extensive peer-reviewed literature supporting its research applications, CJC-1295 with DAC represents a sophisticated tool for exploring the complex biology of the GH-IGF-1 axis. ...........................................

Whether you are exploring endocrine feedback mechanisms, designing metabolic studies, investigating neuroprotective pathways, or researching tissue repair mechanisms, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Order today and experience the eupeptidelap.co.uk difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.